New Topoisomerase I mutations are associated with resistance to camptothecin
New Topoisomerase I mutations are associated with resistance to camptothecin
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Publisher
England: BioMed Central Ltd
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Language
English
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Publisher
England: BioMed Central Ltd
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Topoisomerase I (TOP1) is a nuclear enzyme that catalyzes the relaxation of supercoiled DNA during DNA replication and transcription. TOP1 is the molecular target of camptothecin and related drugs such as irinotecan and SN38 (irinotecan's active metabolite). Irinotecan is widely used as an anti-cancer agent in the treatment of metastatic colon canc...
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Full title
New Topoisomerase I mutations are associated with resistance to camptothecin
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TN_cdi_doaj_primary_oai_doaj_org_article_334a4fd9363b4fe9addc4cca9d60f130
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_334a4fd9363b4fe9addc4cca9d60f130
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ISSN
1476-4598
E-ISSN
1476-4598
DOI
10.1186/1476-4598-10-64
