AM1241 inhibits chondrocyte inflammation and ECM degradation through the Nrf2/HO-1 and NF-κB pathway...
AM1241 inhibits chondrocyte inflammation and ECM degradation through the Nrf2/HO-1 and NF-κB pathways and alleviates osteoarthritis in mice
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Author / Creator
Zou, Zhuan , Pan, Songmu , Sun, Changzheng , Wei, Jiyong , Xu, Yi , Xiao, Kaizhen , Zhao, Jinmin and Gu, Ronghe
Publisher
England: BMC
Journal title
Language
English
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Publication information
Publisher
England: BMC
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Scope and Contents
Contents
This study aimed to investigate the impact of AM1241 on lipopolysaccharide (LPS)-induced chondrocyte inflammation in mice and its potential mechanism for improving osteoarthritis (OA).
The OA mice model was established employing the refined Hulth method. The impact of different concentrations of AM1241 on mice chondrocyte activity was detected u...
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Full title
AM1241 inhibits chondrocyte inflammation and ECM degradation through the Nrf2/HO-1 and NF-κB pathways and alleviates osteoarthritis in mice
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Author / Creator
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_335ebf3e616d415f8a1ecc289c6e7192
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_335ebf3e616d415f8a1ecc289c6e7192
Other Identifiers
ISSN
1528-3658
E-ISSN
1528-3658
DOI
10.1186/s10020-024-01012-5
