miR-135a-5p mediates memory and synaptic impairments via the Rock2/Adducin1 signaling pathway in a m...
miR-135a-5p mediates memory and synaptic impairments via the Rock2/Adducin1 signaling pathway in a mouse model of Alzheimer’s disease
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Author / Creator
Zheng, Kai , Hu, Fan , Zhou, Yang , Zhang, Juan , Zheng, Jie , Lai, Chuan , Xiong, Wan , Cui, Ke , Hu, Ya-Zhuo , Han, Zhi-Tao , Zhang, Hong-Hong , Chen, Jian-Guo , Man, Heng-Ye , Liu, Dan , Lu, Youming and Zhu, Ling-Qiang
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Aberrant regulation of microRNAs (miRNAs) has been implicated in the pathogenesis of Alzheimer’s disease (AD), but most abnormally expressed miRNAs found in AD are not regulated by synaptic activity. Here we report that dysfunction of miR-135a-5p/Rock2/Add1 results in memory/synaptic disorder in a mouse model of AD. miR-135a-5p levels are significa...
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Full title
miR-135a-5p mediates memory and synaptic impairments via the Rock2/Adducin1 signaling pathway in a mouse model of Alzheimer’s disease
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TN_cdi_doaj_primary_oai_doaj_org_article_3366a3bed29948729d65876a46ebc7a7
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_3366a3bed29948729d65876a46ebc7a7
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-021-22196-y
