Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity
Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity
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Author / Creator
He, Hongbin , Jiang, Hua , Chen, Yun , Ye, Jin , Wang, Aoli , Wang, Chao , Liu, Qingsong , Liang, Gaolin , Deng, Xianming , Jiang, Wei and Zhou, Rongbin
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Oridonin (Ori) is the major active ingredient of the traditional Chinese medicinal herb
Rabdosia rubescens
and has anti-inflammatory activity, but the target of Ori remains unknown. NLRP3 is a central component of NLRP3 inflammasome and has been involved in a wide variety of chronic inflammation-driven human diseases. Here, we show that Ori i...
Alternative Titles
Full title
Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity
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TN_cdi_doaj_primary_oai_doaj_org_article_33a471636355469c92084ba342e3fa48
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_33a471636355469c92084ba342e3fa48
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-018-04947-6
