CUG initiation and frameshifting enable production of dipeptide repeat proteins from ALS/FTD C9ORF72...
CUG initiation and frameshifting enable production of dipeptide repeat proteins from ALS/FTD C9ORF72 transcripts
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Expansion of G
4
C
2
repeats in the
C9ORF72
gene is the most prevalent inherited form of amyotrophic lateral sclerosis and frontotemporal dementia. Expanded transcripts undergo repeat-associated non-AUG (RAN) translation producing dipeptide repeat proteins from all reading frames. We determined
cis
-factors and
trans
-...
Alternative Titles
Full title
CUG initiation and frameshifting enable production of dipeptide repeat proteins from ALS/FTD C9ORF72 transcripts
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TN_cdi_doaj_primary_oai_doaj_org_article_3426ab0a50b1414493710f574ce831d4
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_3426ab0a50b1414493710f574ce831d4
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-017-02643-5
