Enhanced CHOLESTEROL biosynthesis promotes breast cancer metastasis via modulating CCDC25 expression...
Enhanced CHOLESTEROL biosynthesis promotes breast cancer metastasis via modulating CCDC25 expression and neutrophil extracellular traps formation
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Author / Creator
Tang, Qiqi , Liang, Beibei , Zhang, Lisha , Li, Xuhui , Li, Hengyu , Jing, Wei , Jiang, Yingjie , Zhou, Felix , Zhang, Jian , Meng, Yanchun , Yang, Xinhua , Yang, Hao , Huang, Gang and Zhao, Jian
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Neutrophil extracellular traps (NETs) has been demonstrated to regulate the metastasis of breast cancer. In this study, we showed that de novo cholesterol biosynthesis induced by ASPP2 depletion in mouse breast cancer cell 4T1 and human breast cancer cell MDA-MB-231 promoted NETs formation in vitro, as well as in lung metastases in mice intravenous...
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Full title
Enhanced CHOLESTEROL biosynthesis promotes breast cancer metastasis via modulating CCDC25 expression and neutrophil extracellular traps formation
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TN_cdi_doaj_primary_oai_doaj_org_article_345421f0d0b341149f363081fa807c3a
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_345421f0d0b341149f363081fa807c3a
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-022-22410-x
