Epigenetic silencing of downstream genes mediated by tandem orientation in lung cancer
Epigenetic silencing of downstream genes mediated by tandem orientation in lung cancer
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Publisher
London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Contents
Epigenetic deregulation is of importance in tumorigenesis. In particular CpG islands (CGI), are frequently hypermethylated. Here, genome-wide DNA-methylation profiles of 480,000 CpGs in lung cancer cells were generated. It was observed that intra- and intergenic CGI exhibited higher methylation compared to normal cells. The functional annotation of...
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Full title
Epigenetic silencing of downstream genes mediated by tandem orientation in lung cancer
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TN_cdi_doaj_primary_oai_doaj_org_article_345716730072453da0e6f7e9e2f438eb
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_345716730072453da0e6f7e9e2f438eb
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-017-04248-w
