SGLT2 inhibition modulates NLRP3 inflammasome activity via ketones and insulin in diabetes with card...
SGLT2 inhibition modulates NLRP3 inflammasome activity via ketones and insulin in diabetes with cardiovascular disease
About this item
Full title
Author / Creator
Kim, So Ra , Lee, Sang-Guk , Kim, Soo Hyun , Kim, Jin Hee , Choi, Eunhye , Cho, Wonhee , Rim, John Hoon , Hwang, Inhwa , Lee, Chan Joo , Lee, Minyoung , Oh, Chang-Myung , Jeon, Justin Y. , Gee, Heon Yung , Kim, Jeong-Ho , Lee, Byung-Wan , Kang, Eun Seok , Cha, Bong-Soo , Lee, Myung-Shik , Yu, Je-Wook , Cho, Jin Won , Kim, Jung-Sun and Lee, Yong-ho
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Sodium–glucose cotransporter 2 (SGLT2) inhibitors reduce cardiovascular events in humans with type 2 diabetes (T2D); however, the underlying mechanism remains unclear. Activation of the NLR family, pyrin domain-containing 3 (NLRP3) inflammasome and subsequent interleukin (IL)-1β release induces atherosclerosis and heart failure. Here we show the ef...
Alternative Titles
Full title
SGLT2 inhibition modulates NLRP3 inflammasome activity via ketones and insulin in diabetes with cardiovascular disease
Authors, Artists and Contributors
Author / Creator
Lee, Sang-Guk
Kim, Soo Hyun
Kim, Jin Hee
Choi, Eunhye
Cho, Wonhee
Rim, John Hoon
Hwang, Inhwa
Lee, Chan Joo
Lee, Minyoung
Oh, Chang-Myung
Jeon, Justin Y.
Gee, Heon Yung
Kim, Jeong-Ho
Lee, Byung-Wan
Kang, Eun Seok
Cha, Bong-Soo
Lee, Myung-Shik
Yu, Je-Wook
Cho, Jin Won
Kim, Jung-Sun
Lee, Yong-ho
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_348deff1539f49598275f21f38cec615
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_348deff1539f49598275f21f38cec615
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-020-15983-6
