Lymphatic endothelium stimulates melanoma metastasis and invasion via MMP14-dependent Notch3 and β1-...
Lymphatic endothelium stimulates melanoma metastasis and invasion via MMP14-dependent Notch3 and β1-integrin activation
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Author / Creator
Pekkonen, Pirita , Alve, Sanni , Balistreri, Giuseppe , Gramolelli, Silvia , Tatti-Bugaeva, Olga , Paatero, Ilkka , Niiranen, Otso , Tuohinto, Krista , Perälä, Nina , Taiwo, Adewale , Zinovkina, Nadezhda , Repo, Pauliina , Icay, Katherine , Ivaska, Johanna , Saharinen, Pipsa , Hautaniemi, Sampsa , Lehti, Kaisa and Ojala, Päivi M
Publisher
England: eLife Sciences Publications Ltd
Journal title
Language
English
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Publisher
England: eLife Sciences Publications Ltd
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Contents
Lymphatic invasion and lymph node metastasis correlate with poor clinical outcome in melanoma. However, the mechanisms of lymphatic dissemination in distant metastasis remain incompletely understood. We show here that exposure of expansively growing human WM852 melanoma cells, but not singly invasive Bowes cells, to lymphatic endothelial cells (LEC...
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Full title
Lymphatic endothelium stimulates melanoma metastasis and invasion via MMP14-dependent Notch3 and β1-integrin activation
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TN_cdi_doaj_primary_oai_doaj_org_article_34f0ebe4bbdf48daa0218c7877779155
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_34f0ebe4bbdf48daa0218c7877779155
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ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.32490
