AURKB as a target in non-small cell lung cancer with acquired resistance to anti-EGFR therapy
AURKB as a target in non-small cell lung cancer with acquired resistance to anti-EGFR therapy
About this item
Full title
Author / Creator
Bertran-Alamillo, Jordi , Cattan, Valérie , Schoumacher, Marie , Codony-Servat, Jordi , Giménez-Capitán, Ana , Cantero, Frédérique , Burbridge, Mike , Rodríguez, Sonia , Teixidó, Cristina , Roman, Ruth , Castellví, Josep , García-Román, Silvia , Codony-Servat, Carles , Viteri, Santiago , Cardona, Andrés-Felipe , Karachaliou, Niki , Rosell, Rafael and Molina-Vila, Miguel-Angel
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Non-small cell lung cancer (NSCLC) tumors harboring mutations in
EGFR
ultimately relapse to therapy with EGFR tyrosine kinase inhibitors (EGFR TKIs). Here, we show that resistant cells without the p.T790M or other acquired mutations are sensitive to the Aurora B (AURKB) inhibitors barasertib and S49076. Phospho-histone H3 (pH3), a major produ...
Alternative Titles
Full title
AURKB as a target in non-small cell lung cancer with acquired resistance to anti-EGFR therapy
Authors, Artists and Contributors
Author / Creator
Cattan, Valérie
Schoumacher, Marie
Codony-Servat, Jordi
Giménez-Capitán, Ana
Cantero, Frédérique
Burbridge, Mike
Rodríguez, Sonia
Teixidó, Cristina
Roman, Ruth
Castellví, Josep
García-Román, Silvia
Codony-Servat, Carles
Viteri, Santiago
Cardona, Andrés-Felipe
Karachaliou, Niki
Rosell, Rafael
Molina-Vila, Miguel-Angel
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_34f8c0286b2b4c818818bdd02b7b3019
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_34f8c0286b2b4c818818bdd02b7b3019
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-09734-5
