Neuropathological and transcriptomic characteristics of the aged brain
Neuropathological and transcriptomic characteristics of the aged brain
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Author / Creator
Miller, Jeremy A , Guillozet-Bongaarts, Angela , Gibbons, Laura E , Postupna, Nadia , Renz, Anne , Beller, Allison E , Sunkin, Susan M , Ng, Lydia , Rose, Shannon E , Smith, Kimberly A , Szafer, Aaron , Barber, Chris , Bertagnolli, Darren , Bickley, Kristopher , Brouner, Krissy , Caldejon, Shiella , Chapin, Mike , Chua, Mindy L , Coleman, Natalie M , Cudaback, Eiron , Cuhaciyan, Christine , Dalley, Rachel A , Dee, Nick , Desta, Tsega , Dolbeare, Tim A , Dotson, Nadezhda I , Fisher, Michael , Gaudreault, Nathalie , Gee, Garrett , Gilbert, Terri L , Goldy, Jeff , Griffin, Fiona , Habel, Caroline , Haradon, Zeb , Hejazinia, Nika , Hellstern, Leanne L , Horvath, Steve , Howard, Kim , Howard, Robert , Johal, Justin , Jorstad, Nikolas L , Josephsen, Samuel R , Kuan, Chihchau L , Lai, Florence , Lee, Eric , Lee, Felix , Lemon, Tracy , Li, Xianwu , Marshall, Desiree A , Melchor, Jose , Mukherjee, Shubhabrata , Nyhus, Julie , Pendergraft, Julie , Potekhina, Lydia , Rha, Elizabeth Y , Rice, Samantha , Rosen, David , Sapru, Abharika , Schantz, Aimee , Shen, Elaine , Sherfield, Emily , Shi, Shu , Sodt, Andy J , Thatra, Nivretta , Tieu, Michael , Wilson, Angela M , Montine, Thomas J , Larson, Eric B , Bernard, Amy , Crane, Paul K , Ellenbogen, Richard G , Keene, C Dirk and Lein, Ed
Publisher
England: eLife Science Publications, Ltd
Journal title
Language
English
Formats
Publication information
Publisher
England: eLife Science Publications, Ltd
Subjects
More information
Scope and Contents
Contents
As more people live longer, age-related neurodegenerative diseases are an increasingly important societal health issue. Treatments targeting specific pathologies such as amyloid beta in Alzheimer’s disease (AD) have not led to effective treatments, and there is increasing evidence of a disconnect between traditional pathology and cognitive abilities with advancing age, indicative of individual variation in resilience to pathology. Here, we generated a comprehensive neuropathological, molecular, and transcriptomic characterization of hippocampus and two regions cortex in 107 aged donors (median = 90) from the Adult Changes in Thought (ACT) study as a freely-available resource (http://aging.brain-map.org/). We confirm established associations between AD pathology and dementia, albeit with increased, presumably aging-related variability, and identify sets of co-expressed genes correlated with pathological tau and inflammation markers. Finally, we demonstrate a relationship between dementia and RNA quality, and find common gene signatures, highli...
Alternative Titles
Full title
Neuropathological and transcriptomic characteristics of the aged brain
Authors, Artists and Contributors
Author / Creator
Guillozet-Bongaarts, Angela
Gibbons, Laura E
Postupna, Nadia
Renz, Anne
Beller, Allison E
Sunkin, Susan M
Ng, Lydia
Rose, Shannon E
Smith, Kimberly A
Szafer, Aaron
Barber, Chris
Bertagnolli, Darren
Bickley, Kristopher
Brouner, Krissy
Caldejon, Shiella
Chapin, Mike
Chua, Mindy L
Coleman, Natalie M
Cudaback, Eiron
Cuhaciyan, Christine
Dalley, Rachel A
Dee, Nick
Desta, Tsega
Dolbeare, Tim A
Dotson, Nadezhda I
Fisher, Michael
Gaudreault, Nathalie
Gee, Garrett
Gilbert, Terri L
Goldy, Jeff
Griffin, Fiona
Habel, Caroline
Haradon, Zeb
Hejazinia, Nika
Hellstern, Leanne L
Horvath, Steve
Howard, Kim
Howard, Robert
Johal, Justin
Jorstad, Nikolas L
Josephsen, Samuel R
Kuan, Chihchau L
Lai, Florence
Lee, Eric
Lee, Felix
Lemon, Tracy
Li, Xianwu
Marshall, Desiree A
Melchor, Jose
Mukherjee, Shubhabrata
Nyhus, Julie
Pendergraft, Julie
Potekhina, Lydia
Rha, Elizabeth Y
Rice, Samantha
Rosen, David
Sapru, Abharika
Schantz, Aimee
Shen, Elaine
Sherfield, Emily
Shi, Shu
Sodt, Andy J
Thatra, Nivretta
Tieu, Michael
Wilson, Angela M
Montine, Thomas J
Larson, Eric B
Bernard, Amy
Crane, Paul K
Ellenbogen, Richard G
Keene, C Dirk
Lein, Ed
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_34f96814eec64ca19f44cf823cbe4aa1
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_34f96814eec64ca19f44cf823cbe4aa1
Other Identifiers
ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.31126
