Upper gut heat shock proteins HSP70 and GRP78 promote insulin resistance, hyperglycemia, and non-alc...
Upper gut heat shock proteins HSP70 and GRP78 promote insulin resistance, hyperglycemia, and non-alcoholic steatohepatitis
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Author / Creator
Angelini, Giulia , Castagneto-Gissey, Lidia , Salinari, Serenella , Bertuzzi, Alessandro , Anello, Danila , Pradhan, Meenakshi , Zschätzsch, Marlen , Ritter, Paul , Le Roux, Carel W. , Rubino, Francesco , Basso, Nicola , Casella, Giovanni , Bornstein, Stefan R. , Tremaroli, Valentina and Mingrone, Geltrude
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
A high-fat diet increases the risk of insulin resistance, type-2 diabetes, and non-alcoholic steato-hepatitis. Here we identified two heat-shock proteins, Heat-Shock-Protein70 and Glucose-Regulated Protein78, which are increased in the jejunum of rats on a high-fat diet. We demonstrated a causal link between these proteins and hepatic and whole-bod...
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Full title
Upper gut heat shock proteins HSP70 and GRP78 promote insulin resistance, hyperglycemia, and non-alcoholic steatohepatitis
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TN_cdi_doaj_primary_oai_doaj_org_article_34fa4b82aec84f178140f4bfe039e94f
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_34fa4b82aec84f178140f4bfe039e94f
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-022-35310-5
