Interferon-γ signaling synergizes with LRRK2 in neurons and microglia derived from human induced plu...
Interferon-γ signaling synergizes with LRRK2 in neurons and microglia derived from human induced pluripotent stem cells
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Panagiotakopoulou, Vasiliki , Ivanyuk, Dina , De Cicco, Silvia , Haq, Wadood , Arsić, Aleksandra , Yu, Cong , Messelodi, Daria , Oldrati, Marvin , Schöndorf, David C. , Perez, Maria-Jose , Cassatella, Ruggiero Pio , Jakobi, Meike , Schneiderhan-Marra, Nicole , Gasser, Thomas , Nikić-Spiegel, Ivana and Deleidi, Michela
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Parkinson’s disease-associated kinase LRRK2 has been linked to IFN type II (IFN-γ) response in infections and to dopaminergic neuronal loss. However, whether and how LRRK2 synergizes with IFN-γ remains unclear. In this study, we employed dopaminergic neurons and microglia differentiated from patient-derived induced pluripotent stem cells carrying
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Interferon-γ signaling synergizes with LRRK2 in neurons and microglia derived from human induced pluripotent stem cells
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TN_cdi_doaj_primary_oai_doaj_org_article_352a040e1e54496bbea8ac57b66898c7
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_352a040e1e54496bbea8ac57b66898c7
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-020-18755-4
