Genome-wide screen reveals Rab12 GTPase as a critical activator of Parkinson’s disease-linked LRRK2...
Genome-wide screen reveals Rab12 GTPase as a critical activator of Parkinson’s disease-linked LRRK2 kinase
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England: eLife Sciences Publications Ltd
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English
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England: eLife Sciences Publications Ltd
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Activating mutations in the leucine-rich repeat kinase 2 (LRRK2) cause Parkinson’s disease. LRRK2 phosphorylates a subset of Rab GTPases, particularly Rab10 and Rab8A, and we showed previously that these phosphoRabs play an important role in LRRK2 membrane recruitment and activation (Vides et al., 2022). To learn more about LRRK2 pathway regulation...
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Genome-wide screen reveals Rab12 GTPase as a critical activator of Parkinson’s disease-linked LRRK2 kinase
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TN_cdi_doaj_primary_oai_doaj_org_article_3565c7f6dcf745449d8d8cc68bd1cf97
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_3565c7f6dcf745449d8d8cc68bd1cf97
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ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.87098
