Chemogenetic ON and OFF switches for RNA virus replication
Chemogenetic ON and OFF switches for RNA virus replication
About this item
Full title
Author / Creator
Heilmann, E. , Kimpel, J. , Hofer, B. , Rössler, A. , Blaas, I. , Egerer, L. , Nolden, T. , Urbiola, C. , Kräusslich, H. G. , Wollmann, G. and von Laer, D.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Therapeutic application of RNA viruses as oncolytic agents or gene vectors requires a tight control of virus activity if toxicity is a concern. Here we present a regulator switch for RNA viruses using a conditional protease approach, in which the function of at least one viral protein essential for transcription and replication is linked to autocat...
Alternative Titles
Full title
Chemogenetic ON and OFF switches for RNA virus replication
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_35bc65b4fdf149b39015ce63f7540b25
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_35bc65b4fdf149b39015ce63f7540b25
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-021-21630-5
