Downregulation of Glutamine Synthetase, not glutaminolysis, is responsible for glutamine addiction i...
Downregulation of Glutamine Synthetase, not glutaminolysis, is responsible for glutamine addiction in Notch1‐driven acute lymphoblastic leukemia
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Author / Creator
Nguyen, Tra Ly , Nokin, Marie‐Julie , Terés, Silvia , Tomé, Mercedes , Bodineau, Clément , Galmar, Oriane , Pasquet, Jean‐Max , Rousseau, Benoit , Liempd, Sebastian , Falcon‐Perez, Juan Manuel , Richard, Elodie , Muzotte, Elodie , Rezvani, Hamid‐Reza , Priault, Muriel , Bouchecareilh, Marion , Redonnet‐Vernhet, Isabelle , Calvo, Julien , Uzan, Benjamin , Pflumio, Françoise , Fuentes, Patricia , Toribio, Maria L. , Khatib, Abdel‐Majid , Soubeyran, Pierre , Murdoch, Piedad del Socorro and Durán, Raúl V.
Publisher
United States: John Wiley & Sons, Inc
Journal title
Language
English
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Publication information
Publisher
United States: John Wiley & Sons, Inc
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More information
Scope and Contents
Contents
During glutamine sufficiency, both Notch‐positive and Notch‐negative T‐ALL cells promote glutamine catabolism, leading to mammalian target of rapamycin complex 1 (mTORC1) activation and cell growth and proliferation. However, during glutamine scarcity, only Notch‐negative T‐ALL cells can perform a metabolic adaptation by promoting glutamine synthes...
Alternative Titles
Full title
Downregulation of Glutamine Synthetase, not glutaminolysis, is responsible for glutamine addiction in Notch1‐driven acute lymphoblastic leukemia
Authors, Artists and Contributors
Author / Creator
Nokin, Marie‐Julie
Terés, Silvia
Tomé, Mercedes
Bodineau, Clément
Galmar, Oriane
Pasquet, Jean‐Max
Rousseau, Benoit
Liempd, Sebastian
Falcon‐Perez, Juan Manuel
Richard, Elodie
Muzotte, Elodie
Rezvani, Hamid‐Reza
Priault, Muriel
Bouchecareilh, Marion
Redonnet‐Vernhet, Isabelle
Calvo, Julien
Uzan, Benjamin
Pflumio, Françoise
Fuentes, Patricia
Toribio, Maria L.
Khatib, Abdel‐Majid
Soubeyran, Pierre
Murdoch, Piedad del Socorro
Durán, Raúl V.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_35c04b323d3d4645a1349eaea077bcd1
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_35c04b323d3d4645a1349eaea077bcd1
Other Identifiers
ISSN
1574-7891,1878-0261
E-ISSN
1878-0261
DOI
10.1002/1878-0261.12877
