Structural insights into the mechanism of leptin receptor activation
Structural insights into the mechanism of leptin receptor activation
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Leptin is an adipocyte-derived protein hormone that promotes satiety and energy homeostasis by activating the leptin receptor (LepR)–STAT3 signaling axis in a subset of hypothalamic neurons. Leptin signaling is dysregulated in obesity, however, where appetite remains elevated despite high levels of circulating leptin. To gain insight into the mecha...
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Structural insights into the mechanism of leptin receptor activation
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TN_cdi_doaj_primary_oai_doaj_org_article_3604942e453f41839c0e226870f2d718
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_3604942e453f41839c0e226870f2d718
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-023-37169-6
