Comprehensive molecular comparison of BRCA1 hypermethylated and BRCA1 mutated triple negative breast...
Comprehensive molecular comparison of BRCA1 hypermethylated and BRCA1 mutated triple negative breast cancers
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Author / Creator
Glodzik, Dominik , Bosch, Ana , Hartman, Johan , Aine, Mattias , Vallon-Christersson, Johan , Reuterswärd, Christel , Karlsson, Anna , Mitra, Shamik , Niméus, Emma , Holm, Karolina , Häkkinen, Jari , Hegardt, Cecilia , Saal, Lao H. , Larsson, Christer , Malmberg, Martin , Rydén, Lisa , Ehinger, Anna , Loman, Niklas , Kvist, Anders , Ehrencrona, Hans , Nik-Zainal, Serena , Borg, Åke , Staaf, Johan , Strategiska forskningsområden (SFO) , Division of Translational Cancer Research , Transl oncogenomics , Biomarkers and epidemiology , The Liquid Biopsy och Tumörprogression i Bröstcancer , Strategic research areas (SRA) , Melanoma Genomics , Tumörcellsbiologi , Breast cancer treatment , Avdelningen för molekylär hematologi , Bröst/lungcancer , Lund University , Tumor Cell Biology , Section V , Breastcancer-genetics , Breast/lungcancer , Other Strong Research Environments , Forskningsgrupp Lungcancer , Avdelningen för klinisk genetik , Transl onkogenomik , Breast cancer Proteogenomics , Lunds universitet , Bröstcancerkirurgi , Familjär bröstcancer , Breast Cancer Surgery , Melanoma , Bröstcancerbehandling , Pathology, Lund , LUCC: Lunds universitets cancercentrum , Övriga starka forskningsmiljöer , Division of Molecular Hematology (DMH) , Melanom , LUCC: Lund University Cancer Centre , Division of Clinical Genetics , Department of Laboratory Medicine , Bröstcancer-genetik , Biomarkörer och Epi , Section I , Department of Clinical Sciences, Lund , Familial Breast Cancer , Avdelningen för translationell cancerforskning , Institutionen för laboratoriemedicin , Breast/ovarian cancer , Sektion V , The Liquid Biopsy and Tumor Progression in Breast Cancer , Profile areas and other strong research environments , Kirurgi, Lund , Faculty of Medicine , Medicinska fakulteten , StemTherapy: National Initiative on Stem Cells for Regenerative Therapy , Molecular therapeutics in breast cancer , Molekylära behandlingsstrategier vid bröstcancer , Patologi, Lund , Institutionen för kliniska vetenskaper, Lund , Research Group Lung Cancer , Sektion I , Surgery (Lund) , Translational Oncogenomics , Profilområden och andra starka forskningsmiljöer , Bröst/ovarialcancer and Bröstcancer Proteogenomik
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Homologous recombination deficiency (HRD) is a defining characteristic in
BRCA
-deficient breast tumors caused by genetic or epigenetic alterations in key pathway genes. We investigated the frequency of
BRCA1
promoter hypermethylation in 237 triple-negative breast cancers (TNBCs) from a population-based study using reported whole genome...
Alternative Titles
Full title
Comprehensive molecular comparison of BRCA1 hypermethylated and BRCA1 mutated triple negative breast cancers
Authors, Artists and Contributors
Author / Creator
Bosch, Ana
Hartman, Johan
Aine, Mattias
Vallon-Christersson, Johan
Reuterswärd, Christel
Karlsson, Anna
Mitra, Shamik
Niméus, Emma
Holm, Karolina
Häkkinen, Jari
Hegardt, Cecilia
Saal, Lao H.
Larsson, Christer
Malmberg, Martin
Rydén, Lisa
Ehinger, Anna
Loman, Niklas
Kvist, Anders
Ehrencrona, Hans
Nik-Zainal, Serena
Borg, Åke
Staaf, Johan
Strategiska forskningsområden (SFO)
Division of Translational Cancer Research
Transl oncogenomics
Biomarkers and epidemiology
The Liquid Biopsy och Tumörprogression i Bröstcancer
Strategic research areas (SRA)
Melanoma Genomics
Tumörcellsbiologi
Breast cancer treatment
Avdelningen för molekylär hematologi
Bröst/lungcancer
Lund University
Tumor Cell Biology
Section V
Breastcancer-genetics
Breast/lungcancer
Other Strong Research Environments
Forskningsgrupp Lungcancer
Avdelningen för klinisk genetik
Transl onkogenomik
Breast cancer Proteogenomics
Lunds universitet
Bröstcancerkirurgi
Familjär bröstcancer
Breast Cancer Surgery
Melanoma
Bröstcancerbehandling
Pathology, Lund
LUCC: Lunds universitets cancercentrum
Övriga starka forskningsmiljöer
Division of Molecular Hematology (DMH)
Melanom
LUCC: Lund University Cancer Centre
Division of Clinical Genetics
Department of Laboratory Medicine
Bröstcancer-genetik
Biomarkörer och Epi
Section I
Department of Clinical Sciences, Lund
Familial Breast Cancer
Avdelningen för translationell cancerforskning
Institutionen för laboratoriemedicin
Breast/ovarian cancer
Sektion V
The Liquid Biopsy and Tumor Progression in Breast Cancer
Profile areas and other strong research environments
Kirurgi, Lund
Faculty of Medicine
Medicinska fakulteten
StemTherapy: National Initiative on Stem Cells for Regenerative Therapy
Molecular therapeutics in breast cancer
Molekylära behandlingsstrategier vid bröstcancer
Patologi, Lund
Institutionen för kliniska vetenskaper, Lund
Research Group Lung Cancer
Sektion I
Surgery (Lund)
Translational Oncogenomics
Profilområden och andra starka forskningsmiljöer
Bröst/ovarialcancer
Bröstcancer Proteogenomik
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_364ce59486504bf6a831a413fa23b595
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_364ce59486504bf6a831a413fa23b595
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-020-17537-2
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