The PARP inhibitor olaparib potentiates the effect of the DNA damaging agent doxorubicin in osteosar...
The PARP inhibitor olaparib potentiates the effect of the DNA damaging agent doxorubicin in osteosarcoma
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England: BioMed Central Ltd
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Language
English
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England: BioMed Central Ltd
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PARP1 facilitates the recovery of DNA-damaged cells by recruiting DNA damage response molecules such as γH2AX and BRCA1/2, and plays a role in resistance to antitumor therapies. Therefore, PARP inhibition being evaluated as an anti-cancer therapy. However, there are limited studies regrading PARP inhibition in osteosarcoma.
We evaluated the expr...
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The PARP inhibitor olaparib potentiates the effect of the DNA damaging agent doxorubicin in osteosarcoma
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TN_cdi_doaj_primary_oai_doaj_org_article_36ab567ef66543dc840a81097a233d43
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_36ab567ef66543dc840a81097a233d43
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ISSN
1756-9966,0392-9078
E-ISSN
1756-9966
DOI
10.1186/s13046-018-0772-9
