Administration of nucleoside-modified mRNA encoding broadly neutralizing antibody protects humanized...
Administration of nucleoside-modified mRNA encoding broadly neutralizing antibody protects humanized mice from HIV-1 challenge
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Author / Creator
Pardi, Norbert , Secreto, Anthony J. , Shan, Xiaochuan , Debonera, Fotini , Glover, Joshua , Yi, Yanjie , Muramatsu, Hiromi , Ni, Houping , Mui, Barbara L. , Tam, Ying K. , Shaheen, Farida , Collman, Ronald G. , Karikó, Katalin , Danet-Desnoyers, Gwenn A. , Madden, Thomas D. , Hope, Michael J. and Weissman, Drew
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Monoclonal antibodies are one of the fastest growing classes of pharmaceutical products, however, their potential is limited by the high cost of development and manufacturing. Here we present a safe and cost-effective platform for
in vivo
expression of therapeutic antibodies using nucleoside-modified mRNA. To demonstrate feasibility and prote...
Alternative Titles
Full title
Administration of nucleoside-modified mRNA encoding broadly neutralizing antibody protects humanized mice from HIV-1 challenge
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_36f809ffcf28468fac50f32ddc0d7fa0
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_36f809ffcf28468fac50f32ddc0d7fa0
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms14630
