A spontaneous mitonuclear epistasis converging on Rieske Fe-S protein exacerbates complex III defici...
A spontaneous mitonuclear epistasis converging on Rieske Fe-S protein exacerbates complex III deficiency in mice
About this item
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Author / Creator
Purhonen, Janne , Grigorjev, Vladislav , Ekiert, Robert , Aho, Noora , Rajendran, Jayasimman , Pietras, Rafał , Truvé, Katarina , Wikström, Mårten , Sharma, Vivek , Osyczka, Artur , Fellman, Vineta , Kallijärvi, Jukka , Faculty of Medicine , Department of Clinical Sciences, Lund , Medicinska fakulteten , Paediatrics (Lund) , Lund University , Sektion V , Pediatrik, Lund , Section V , Institutionen för kliniska vetenskaper, Lund and Lunds universitet
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
We previously observed an unexpected fivefold (35 vs. 200 days) difference in the survival of respiratory chain complex III (CIII) deficient
Bcs1l
p.S78G
mice between two congenic backgrounds. Here, we identify a spontaneous homoplasmic mtDNA variant (
m.G14904A
,
mt-Cyb
p.D254N
), affecting the CIII subunit cytochrome b (MT...
Alternative Titles
Full title
A spontaneous mitonuclear epistasis converging on Rieske Fe-S protein exacerbates complex III deficiency in mice
Authors, Artists and Contributors
Author / Creator
Grigorjev, Vladislav
Ekiert, Robert
Aho, Noora
Rajendran, Jayasimman
Pietras, Rafał
Truvé, Katarina
Wikström, Mårten
Sharma, Vivek
Osyczka, Artur
Fellman, Vineta
Kallijärvi, Jukka
Faculty of Medicine
Department of Clinical Sciences, Lund
Medicinska fakulteten
Paediatrics (Lund)
Lund University
Sektion V
Pediatrik, Lund
Section V
Institutionen för kliniska vetenskaper, Lund
Lunds universitet
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_3779b9d3fc13415ab6b4e35cb40df347
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_3779b9d3fc13415ab6b4e35cb40df347
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-14201-2
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