Increased formate overflow is a hallmark of oxidative cancer
Increased formate overflow is a hallmark of oxidative cancer
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Author / Creator
Meiser, Johannes , Schuster, Anne , Pietzke, Matthias , Vande Voorde, Johan , Athineos, Dimitris , Oizel, Kristell , Burgos-Barragan, Guillermo , Wit, Niek , Dhayade, Sandeep , Morton, Jennifer P. , Dornier, Emmanuel , Sumpton, David , Mackay, Gillian M. , Blyth, Karen , Patel, Ketan J. , Niclou, Simone P. and Vazquez, Alexei
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Formate overflow coupled to mitochondrial oxidative metabolism\ has been observed in cancer cell lines, but whether that takes place in the tumor microenvironment is not known. Here we report the observation of serine catabolism to formate in normal murine tissues, with a relative rate correlating with serine levels and the tissue oxidative state....
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Full title
Increased formate overflow is a hallmark of oxidative cancer
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TN_cdi_doaj_primary_oai_doaj_org_article_3791b6fce2b1446482c02c147ec6dfd2
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_3791b6fce2b1446482c02c147ec6dfd2
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-018-03777-w
