Distinct promoter methylation profile reveals spatial epigenetic heterogeneity in 2 myeloma patients...
Distinct promoter methylation profile reveals spatial epigenetic heterogeneity in 2 myeloma patients with multifocal extramedullary relapses
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Germany: BioMed Central Ltd
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English
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Germany: BioMed Central Ltd
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Spatial and subclonal genetic heterogeneity in multiple myeloma (MM) have been demonstrated by sequencing of plasma cells from multi-focal regions, but studies of spatial epigenetic heterogeneity are scanty. Herein, promoter methylation status of genes implicated in disease progression (CDKN2A and SHP1) and marrow escape (CDH1, CD56, and CXCR4) was...
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Distinct promoter methylation profile reveals spatial epigenetic heterogeneity in 2 myeloma patients with multifocal extramedullary relapses
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TN_cdi_doaj_primary_oai_doaj_org_article_37d552c1c0d04792b9a57adbab99d54c
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_37d552c1c0d04792b9a57adbab99d54c
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ISSN
1868-7075,1868-7083
E-ISSN
1868-7083,1868-7075
DOI
10.1186/s13148-018-0597-6
