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Precisely measured protein lifetimes in the mouse brain reveal differences across tissues and subcel...

Precisely measured protein lifetimes in the mouse brain reveal differences across tissues and subcel...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_37f09442e22e41daa48bdc27c646c649

Precisely measured protein lifetimes in the mouse brain reveal differences across tissues and subcellular fractions

About this item

Full title

Precisely measured protein lifetimes in the mouse brain reveal differences across tissues and subcellular fractions

Publisher

London: Nature Publishing Group UK

Journal title

Nature communications, 2018-10, Vol.9 (1), p.4230-17, Article 4230

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

The turnover of brain proteins is critical for organism survival, and its perturbations are linked to pathology. Nevertheless, protein lifetimes have been difficult to obtain in vivo. They are readily measured in vitro by feeding cells with isotopically labeled amino acids, followed by mass spectrometry analyses. In vivo proteins are generated from...

Alternative Titles

Full title

Precisely measured protein lifetimes in the mouse brain reveal differences across tissues and subcellular fractions

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_doaj_primary_oai_doaj_org_article_37f09442e22e41daa48bdc27c646c649

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_37f09442e22e41daa48bdc27c646c649

Other Identifiers

ISSN

2041-1723

E-ISSN

2041-1723

DOI

10.1038/s41467-018-06519-0

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