Replication fork reversal triggers fork degradation in BRCA2-defective cells
Replication fork reversal triggers fork degradation in BRCA2-defective cells
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Besides its role in homologous recombination, the tumor suppressor
BRCA2
protects stalled replication forks from nucleolytic degradation. Defective fork stability contributes to chemotherapeutic sensitivity of
BRCA2
-defective tumors by yet-elusive mechanisms. Using DNA fiber spreading and direct visualization of replication intermediat...
Alternative Titles
Full title
Replication fork reversal triggers fork degradation in BRCA2-defective cells
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TN_cdi_doaj_primary_oai_doaj_org_article_37f10f169bf74902a273599741eefa33
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_37f10f169bf74902a273599741eefa33
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-017-01164-5
