A truncating mutation in the autophagy gene UVRAG drives inflammation and tumorigenesis in mice
A truncating mutation in the autophagy gene UVRAG drives inflammation and tumorigenesis in mice
About this item
Full title
Author / Creator
Quach, Christine , Song, Ying , Guo, Hongrui , Li, Shun , Maazi, Hadi , Fung, Marshall , Sands, Nathaniel , O’Connell, Douglas , Restrepo-Vassalli, Sara , Chai, Billy , Nemecio, Dali , Punj, Vasu , Akbari, Omid , Idos, Gregory E. , Mumenthaler, Shannon M. , Wu, Nancy , Martin, Sue Ellen , Hagiya, Ashley , Hicks, James , Cui, Hengmin and Liang, Chengyu
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
Aberrant autophagy is a major risk factor for inflammatory diseases and cancer. However, the genetic basis and underlying mechanisms are less established. UVRAG is a tumor suppressor candidate involved in autophagy, which is truncated in cancers by a frameshift (FS) mutation and expressed as a shortened UVRAG
FS
. To investigate the role of U...
Alternative Titles
Full title
A truncating mutation in the autophagy gene UVRAG drives inflammation and tumorigenesis in mice
Authors, Artists and Contributors
Author / Creator
Song, Ying
Guo, Hongrui
Li, Shun
Maazi, Hadi
Fung, Marshall
Sands, Nathaniel
O’Connell, Douglas
Restrepo-Vassalli, Sara
Chai, Billy
Nemecio, Dali
Punj, Vasu
Akbari, Omid
Idos, Gregory E.
Mumenthaler, Shannon M.
Wu, Nancy
Martin, Sue Ellen
Hagiya, Ashley
Hicks, James
Cui, Hengmin
Liang, Chengyu
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_3853dd7ac3f64a118db62600822a7e0c
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_3853dd7ac3f64a118db62600822a7e0c
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-13475-w
