JMJD4-demethylated RIG-I prevents hepatic steatosis and carcinogenesis
JMJD4-demethylated RIG-I prevents hepatic steatosis and carcinogenesis
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Li, Zhenyang , Zhou, Ye , Jia, Kaiwei , Yang, Yingyun , Zhang, Liyuan , Wang, Suyuan , Dong, Yue , Wang, Mu , Li, Yunhui , Lu, Shan , Zhang, Wannian , Zhang, Luxin , Fan, Yiwen , Zhang, Dingji , Li, Nan , Yu, Yizhi , Cao, Xuetao and Hou, Jin
Publisher
London: BioMed Central Ltd
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English
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London: BioMed Central Ltd
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Background Hepatocarcinogenesis is driven by necroinflammation or metabolic disorders, and the underlying mechanisms remain largely elusive. We previously found that retinoic acid-inducible gene-I (RIG-I), a sensor for recognizing RNA virus in innate immune cells, is mainly expressed by parenchymal hepatocytes in the liver. However, its roles in he...
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Full title
JMJD4-demethylated RIG-I prevents hepatic steatosis and carcinogenesis
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TN_cdi_doaj_primary_oai_doaj_org_article_385d3a677e4f4b8c9d311976fb9a1d06
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_385d3a677e4f4b8c9d311976fb9a1d06
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ISSN
1756-8722
E-ISSN
1756-8722
DOI
10.1186/s13045-022-01381-6
