Crosstalk between MSH2–MSH3 and polβ promotes trinucleotide repeat expansion during base excision re...
Crosstalk between MSH2–MSH3 and polβ promotes trinucleotide repeat expansion during base excision repair
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Studies in knockout mice provide evidence that MSH2–MSH3 and the BER machinery promote trinucleotide repeat (TNR) expansion, yet how these two different repair pathways cause the mutation is unknown. Here we report the first molecular crosstalk mechanism, in which MSH2–MSH3 is used as a component of the BER machinery to cause expansion. On its own,...
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Crosstalk between MSH2–MSH3 and polβ promotes trinucleotide repeat expansion during base excision repair
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TN_cdi_doaj_primary_oai_doaj_org_article_3879ba8a8aee40aca671630c5cc0af1e
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_3879ba8a8aee40aca671630c5cc0af1e
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms12465
