Hypomorphic Brca2 and Rad51c double mutant mice display Fanconi anemia, cancer and polygenic replica...
Hypomorphic Brca2 and Rad51c double mutant mice display Fanconi anemia, cancer and polygenic replication stress
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
The prototypic cancer-predisposition disease Fanconi Anemia (FA) is identified by biallelic mutations in any one of twenty-three
FANC
genes. Puzzlingly, inactivation of one
Fanc
gene alone in mice fails to faithfully model the pleiotropic human disease without additional external stress. Here we find that FA patients frequently display<...
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Hypomorphic Brca2 and Rad51c double mutant mice display Fanconi anemia, cancer and polygenic replication stress
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TN_cdi_doaj_primary_oai_doaj_org_article_388412a5d9a24c389d84b1801b5d84c2
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_388412a5d9a24c389d84b1801b5d84c2
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-023-36933-y
