Tau polarizes an aging transcriptional signature to excitatory neurons and glia
Tau polarizes an aging transcriptional signature to excitatory neurons and glia
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England: eLife Sciences Publications Ltd
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Language
English
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England: eLife Sciences Publications Ltd
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Aging is a major risk factor for Alzheimer’s disease (AD), and cell-type vulnerability underlies its characteristic clinical manifestations. We have performed longitudinal, single-cell RNA-sequencing in
Drosophila
with pan-neuronal expression of human tau, which forms AD neurofibrillary tangle pathology. Whereas tau- and aging-induced gene ex...
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Full title
Tau polarizes an aging transcriptional signature to excitatory neurons and glia
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TN_cdi_doaj_primary_oai_doaj_org_article_38917c6a7164451fa76d94b52a50b80c
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_38917c6a7164451fa76d94b52a50b80c
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ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.85251
