Secreted IgM deficiency leads to increased BCR signaling that results in abnormal splenic B cell dev...
Secreted IgM deficiency leads to increased BCR signaling that results in abnormal splenic B cell development
About this item
Full title
Author / Creator
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Mice lacking secreted IgM (
sIgM
−/−
) antibodies display abnormal splenic B cell development, which results in increased marginal zone and decreased follicular B cell numbers. However, the mechanism by which sIgM exhibit this effect is unknown. Here, we demonstrate that B cells in
sIgM
−/−
mice display increased B cell receptor (...
Alternative Titles
Full title
Secreted IgM deficiency leads to increased BCR signaling that results in abnormal splenic B cell development
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_3895420cee06482aa60c257f0ce6ddf6
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_3895420cee06482aa60c257f0ce6ddf6
Other Identifiers
ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-017-03688-8
