Cancer-associated mutations reveal a novel role for EpCAM as an inhibitor of cathepsin-L and tumor c...
Cancer-associated mutations reveal a novel role for EpCAM as an inhibitor of cathepsin-L and tumor cell invasion
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Publisher
England: BioMed Central Ltd
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Language
English
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Publisher
England: BioMed Central Ltd
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EpCAM (Epithelial cell adhesion molecule) is often dysregulated in epithelial cancers. Prior studies implicate EpCAM in the regulation of oncogenic signaling pathways and epithelial-to-mesenchymal transition. It was recently demonstrated that EpCAM contains a thyroglobulin type-1 (TY-1) domain. Multiple proteins with TY-1 domains are known to inhib...
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Cancer-associated mutations reveal a novel role for EpCAM as an inhibitor of cathepsin-L and tumor cell invasion
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TN_cdi_doaj_primary_oai_doaj_org_article_38b6284507a6410392762012b6929067
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_38b6284507a6410392762012b6929067
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ISSN
1471-2407
E-ISSN
1471-2407
DOI
10.1186/s12885-021-08239-z
