Caveolin-1 temporal modulation enhances antibody drug efficacy in heterogeneous gastric cancer
Caveolin-1 temporal modulation enhances antibody drug efficacy in heterogeneous gastric cancer
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Resistance mechanisms and heterogeneity in HER2-positive gastric cancers (GC) limit Trastuzumab benefit in 32% of patients, and other targeted therapies have failed in clinical trials. Using patient samples, patient-derived xenografts (PDXs), partially humanized biological models, and HER2-targeted imaging technologies we demonstrate the role of ca...
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Full title
Caveolin-1 temporal modulation enhances antibody drug efficacy in heterogeneous gastric cancer
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TN_cdi_doaj_primary_oai_doaj_org_article_38bd18f4fd924b1c8813870074036bf4
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_38bd18f4fd924b1c8813870074036bf4
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-022-30142-9
