Identification of drug-specific public TCR driving severe cutaneous adverse reactions
Identification of drug-specific public TCR driving severe cutaneous adverse reactions
About this item
Full title
Author / Creator
Pan, Ren-You , Chu, Mu-Tzu , Wang, Chuang-Wei , Lee, Yun-Shien , Lemonnier, Francois , Michels, Aaron W. , Schutte, Ryan , Ostrov, David A. , Chen, Chun-Bing , Phillips, Elizabeth Jane , Mallal, Simon Alexander , Mockenhaupt, Maja , Bellón, Teresa , Tassaneeyakul, Wichittra , White, Katie D. , Roujeau, Jean-Claude , Chung, Wen-Hung and Hung, Shuen-Iu
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Drug hypersensitivity such as severe cutaneous adverse reactions (SCAR), including Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), could be life-threatening. Here, we enroll SCAR patients to investigate the T cell receptor (TCR) repertoire by next-generation sequencing. A public αβTCR is identified from the cytotoxic T lymphocy...
Alternative Titles
Full title
Identification of drug-specific public TCR driving severe cutaneous adverse reactions
Authors, Artists and Contributors
Author / Creator
Chu, Mu-Tzu
Wang, Chuang-Wei
Lee, Yun-Shien
Lemonnier, Francois
Michels, Aaron W.
Schutte, Ryan
Ostrov, David A.
Chen, Chun-Bing
Phillips, Elizabeth Jane
Mallal, Simon Alexander
Mockenhaupt, Maja
Bellón, Teresa
Tassaneeyakul, Wichittra
White, Katie D.
Roujeau, Jean-Claude
Chung, Wen-Hung
Hung, Shuen-Iu
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_38d2c02fdc28404082a384a33f386ffd
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_38d2c02fdc28404082a384a33f386ffd
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-11396-2
