Nuclear localization of TET2 requires β-catenin activation and correlates with favourable prognosis...
Nuclear localization of TET2 requires β-catenin activation and correlates with favourable prognosis in colorectal cancer
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Author / Creator
Li, Changpeng , He, Jingcai , Meng, Fei , Wang, Fuhui , Sun, Hao , Zhang, Huizhong , Dong, Linna , Zhang, Mengdan , Xu, Qiaoran , Liang, Lining , Li, Yuan , Yang, Tingting , He, Meiai , Wang, Tao , Lin, Jiechun , Sun, Jiaqi , Huang, Qiuling , Guo, Lin , Zhang, Xiaofei , Mai, Shijuan and Zheng, Hui
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Mutation-induced malfunction of ten-eleven translocation methylcytosine dioxygenase 2 (TET2) is widely reported in haematological malignancies. However, the role of TET2 in solid cancers, including colorectal cancer (CRC), is unclear. Here, we found that TET2 malfunction in CRC is mostly due to decreased nuclear localization and that nuclear locali...
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Full title
Nuclear localization of TET2 requires β-catenin activation and correlates with favourable prognosis in colorectal cancer
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TN_cdi_doaj_primary_oai_doaj_org_article_3904242384354c15bb6b792c65eb25e1
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_3904242384354c15bb6b792c65eb25e1
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ISSN
2041-4889
E-ISSN
2041-4889
DOI
10.1038/s41419-023-06038-x
