Pharmacological targeting of P300/CBP reveals EWS::FLI1-mediated senescence evasion in Ewing sarcoma
Pharmacological targeting of P300/CBP reveals EWS::FLI1-mediated senescence evasion in Ewing sarcoma
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England: BioMed Central Ltd
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English
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Publisher
England: BioMed Central Ltd
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Ewing sarcoma (ES) poses a significant therapeutic challenge due to the difficulty in targeting its main oncodriver, EWS::FLI1. We show that pharmacological targeting of the EWS::FLI1 transcriptional complex via inhibition of P300/CBP drives a global transcriptional outcome similar to direct knockdown of EWS::FLI1, and furthermore yields prognostic...
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Full title
Pharmacological targeting of P300/CBP reveals EWS::FLI1-mediated senescence evasion in Ewing sarcoma
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TN_cdi_doaj_primary_oai_doaj_org_article_3923b7e698e143889b1d963ad608e92e
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_3923b7e698e143889b1d963ad608e92e
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ISSN
1476-4598
E-ISSN
1476-4598
DOI
10.1186/s12943-024-02115-7
