A feed-forward pathway drives LRRK2 kinase membrane recruitment and activation
A feed-forward pathway drives LRRK2 kinase membrane recruitment and activation
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England: eLife Sciences Publications Ltd
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English
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England: eLife Sciences Publications Ltd
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Activating mutations in the leucine-rich repeat kinase 2 (LRRK2) cause Parkinson’s disease, and previously we showed that activated LRRK2 phosphorylates a subset of Rab GTPases (Steger et al., 2017). Moreover, Golgi-associated Rab29 can recruit LRRK2 to the surface of the Golgi and activate it there for both auto- and Rab substrate phosphorylation....
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A feed-forward pathway drives LRRK2 kinase membrane recruitment and activation
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TN_cdi_doaj_primary_oai_doaj_org_article_3925beaf71f0417ebbc0fd002e21efb5
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_3925beaf71f0417ebbc0fd002e21efb5
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ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.79771
