Delineating the stepwise millisecond allosteric activation mechanism of the class C GPCR dimer mGlu5
Delineating the stepwise millisecond allosteric activation mechanism of the class C GPCR dimer mGlu5
About this item
Full title
Author / Creator
Li, Mingyu , Lan, Xiaobing , Shi, Xinchao , Zhu, Chunhao , Lu, Xun , Pu, Jun , Lu, Shaoyong and Zhang, Jian
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Two-thirds of signaling hormones and one-third of approved drugs exert their effects by binding and modulating the G protein-coupled receptors (GPCRs) activation. While the activation mechanism for monomeric GPCRs has been well-established, little is known about GPCRs in dimeric form. Here, by combining transition pathway generation, extensive atom...
Alternative Titles
Full title
Delineating the stepwise millisecond allosteric activation mechanism of the class C GPCR dimer mGlu5
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Author / Creator
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_39581e53858b473cb5cb3cd8bbfd4905
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_39581e53858b473cb5cb3cd8bbfd4905
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-024-51999-y
