Competitive oxidation and ubiquitylation on the evolutionarily conserved cysteine confer tissue-spec...
Competitive oxidation and ubiquitylation on the evolutionarily conserved cysteine confer tissue-specific stabilization of Insig-2
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Author / Creator
Zhou, Zhang-Sen , Li, Mei-Xin , Liu, Jie , Jiao, Hengwu , Xia, Jing-Ming , Shi, Xiong-Jie , Zhao, Huabin , Chu, Liping , Liu, Jingrong , Qi, Wei , Luo, Jie and Song, Bao-Liang
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Insig-2 is an ER membrane protein negatively controlling lipid biosynthesis. Here, we find that Insig-2 is increased in the tissues, including liver, but unaltered in the muscle of
gp78
-deficient mice. In hepatocytes and undifferentiated C2C12 myoblasts, Insig-2 is ubiquitylated on Cys215 by gp78 and degraded. However, the C215 residue is ox...
Alternative Titles
Full title
Competitive oxidation and ubiquitylation on the evolutionarily conserved cysteine confer tissue-specific stabilization of Insig-2
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_39cecb221deb45dc9f684b805dec75f2
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_39cecb221deb45dc9f684b805dec75f2
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-14231-w
