High expression of PLA2G2A in fibroblasts plays a crucial role in the early progression of carotid a...
High expression of PLA2G2A in fibroblasts plays a crucial role in the early progression of carotid atherosclerosis
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Author / Creator
Wang, Xin , Li, Shen , Liu, Chen , Zhao, Jiawei , Ren, Gangfeng , Zhang, Feng , Liu, Xuyang , Cao, Shuang , Xu, Yuming and Xia, Zongping
Publisher
England: BioMed Central Ltd
Journal title
Language
English
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Publication information
Publisher
England: BioMed Central Ltd
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Contents
In mouse models of atherosclerosis, knockout of the PLA2G2A gene has been shown to reduce the volume of atherosclerotic plaques. Clinical trials have demonstrated the potential of using the sPLA2 inhibitor Varespladib in combination with statins to reduce lipid levels. However, this approach has not yielded the expected results in reducing the risk...
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Full title
High expression of PLA2G2A in fibroblasts plays a crucial role in the early progression of carotid atherosclerosis
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_39e438bfc66047b1a751b7ca8808a0e4
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_39e438bfc66047b1a751b7ca8808a0e4
Other Identifiers
ISSN
1479-5876
E-ISSN
1479-5876
DOI
10.1186/s12967-024-05679-6
