The prefoldin complex stabilizes the von Hippel-Lindau protein against aggregation and degradation
The prefoldin complex stabilizes the von Hippel-Lindau protein against aggregation and degradation
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Contents
Loss of von Hippel-Lindau protein pVHL function promotes VHL diseases, including sporadic and inherited clear cell Renal Cell Carcinoma (ccRCC). Mechanisms controlling pVHL function and regulation, including folding and stability, remain elusive. Here, we have identified the conserved cochaperone prefoldin complex in a screen for pVHL interactors....
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Full title
The prefoldin complex stabilizes the von Hippel-Lindau protein against aggregation and degradation
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TN_cdi_doaj_primary_oai_doaj_org_article_3a166122c1164e179524bd21321b7177
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_3a166122c1164e179524bd21321b7177
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ISSN
1553-7404,1553-7390
E-ISSN
1553-7404
DOI
10.1371/journal.pgen.1009183
