Structural insight into the bulge-containing KRAS oncogene promoter G-quadruplex bound to berberine...
Structural insight into the bulge-containing KRAS oncogene promoter G-quadruplex bound to berberine and coptisine
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
KRAS is one of the most highly mutated oncoproteins, which is overexpressed in various human cancers and implicated in poor survival. The G-quadruplex formed in
KRAS
oncogene promoter (
KRAS
-G4) is a transcriptional modulator and amenable to small molecule targeting. However, no available
KRAS
-G4-ligand complex structure has yet...
Alternative Titles
Full title
Structural insight into the bulge-containing KRAS oncogene promoter G-quadruplex bound to berberine and coptisine
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TN_cdi_doaj_primary_oai_doaj_org_article_3a3ab16b284641808c7b23a21ff63551
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_3a3ab16b284641808c7b23a21ff63551
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-022-33761-4
