Digital twins elucidate critical role of Tscm in clinical persistence of TCR-engineered cell therapy
Digital twins elucidate critical role of Tscm in clinical persistence of TCR-engineered cell therapy
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Despite recent progress in adoptive T cell therapy for cancer, understanding and predicting the kinetics of infused T cells remains a challenge. Multiple factors can impact the distribution, expansion, and decay or persistence of infused T cells in patients. We have developed a novel quantitative systems pharmacology (QSP) model of TCR-transgenic T...
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Digital twins elucidate critical role of Tscm in clinical persistence of TCR-engineered cell therapy
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TN_cdi_doaj_primary_oai_doaj_org_article_3a87a9a0cb4f4227b3ae4c85f13adb9b
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_3a87a9a0cb4f4227b3ae4c85f13adb9b
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2056-7189
E-ISSN
2056-7189
DOI
10.1038/s41540-024-00335-7
