Mitochondrial CaMKII causes adverse metabolic reprogramming and dilated cardiomyopathy
Mitochondrial CaMKII causes adverse metabolic reprogramming and dilated cardiomyopathy
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Author / Creator
Luczak, Elizabeth D. , Wu, Yuejin , Granger, Jonathan M. , Joiner, Mei-ling A. , Wilson, Nicholas R. , Gupta, Ashish , Umapathi, Priya , Murphy, Kevin R. , Reyes Gaido, Oscar E. , Sabet, Amin , Corradini, Eleonora , Tseng, Wen-Wei , Wang, Yibin , Heck, Albert J. R. , Wei, An-Chi , Weiss, Robert G. and Anderson, Mark E.
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Despite the clear association between myocardial injury, heart failure and depressed myocardial energetics, little is known about upstream signals responsible for remodeling myocardial metabolism after pathological stress. Here, we report increased mitochondrial calmodulin kinase II (CaMKII) activation and left ventricular dilation in mice one week...
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Full title
Mitochondrial CaMKII causes adverse metabolic reprogramming and dilated cardiomyopathy
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TN_cdi_doaj_primary_oai_doaj_org_article_3a9e4d2ef5934da08394c8adbae0c995
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_3a9e4d2ef5934da08394c8adbae0c995
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-020-18165-6
