Prime editing in mice reveals the essentiality of a single base in driving tissue-specific gene expr...
Prime editing in mice reveals the essentiality of a single base in driving tissue-specific gene expression
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Author / Creator
Gao, Pan , Lyu, Qing , Ghanam, Amr R. , Lazzarotto, Cicera R. , Newby, Gregory A. , Zhang, Wei , Choi, Mihyun , Slivano, Orazio J. , Holden, Kevin , Walker, John A. , Kadina, Anastasia P. , Munroe, Rob J. , Abratte, Christian M. , Schimenti, John C. , Liu, David R. , Tsai, Shengdar Q. , Long, Xiaochun and Miano, Joseph M.
Publisher
England: BioMed Central Ltd
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Language
English
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Publisher
England: BioMed Central Ltd
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Contents
Most single nucleotide variants (SNVs) occur in noncoding sequence where millions of transcription factor binding sites (TFBS) reside. Here, a comparative analysis of CRISPR-mediated homology-directed repair (HDR) versus the recently reported prime editing 2 (PE2) system was carried out in mice over a TFBS called a CArG box in the Tspan2 promoter.<...
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Full title
Prime editing in mice reveals the essentiality of a single base in driving tissue-specific gene expression
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TN_cdi_doaj_primary_oai_doaj_org_article_3ae7242cf5e844faa32def1a4de9bd76
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_3ae7242cf5e844faa32def1a4de9bd76
Other Identifiers
ISSN
1474-760X,1474-7596
E-ISSN
1474-760X
DOI
10.1186/s13059-021-02304-3
