Acute depletion of CTCF rewires genome-wide chromatin accessibility
Acute depletion of CTCF rewires genome-wide chromatin accessibility
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Publisher
England: BioMed Central Ltd
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Language
English
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Publisher
England: BioMed Central Ltd
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Contents
The transcription factor CTCF appears indispensable in defining topologically associated domain boundaries and maintaining chromatin loop structures within these domains, supported by numerous functional studies. However, acute depletion of CTCF globally reduces chromatin interactions but does not significantly alter transcription.
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Full title
Acute depletion of CTCF rewires genome-wide chromatin accessibility
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TN_cdi_doaj_primary_oai_doaj_org_article_3af666db8ed9486ba062ca3e3c397961
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_3af666db8ed9486ba062ca3e3c397961
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ISSN
1474-760X,1474-7596
E-ISSN
1474-760X
DOI
10.1186/s13059-021-02466-0
