Designed peptides as nanomolar cross-amyloid inhibitors acting via supramolecular nanofiber co-assem...
Designed peptides as nanomolar cross-amyloid inhibitors acting via supramolecular nanofiber co-assembly
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Author / Creator
Taş, Karin , Volta, Beatrice Dalla , Lindner, Christina , El Bounkari, Omar , Hille, Kathleen , Tian, Yuan , Puig-Bosch, Xènia , Ballmann, Markus , Hornung, Simon , Ortner, Martin , Prem, Sophia , Meier, Laura , Rammes, Gerhard , Haslbeck, Martin , Weber, Christian , Megens, Remco T. A. , Bernhagen, Jürgen and Kapurniotu, Aphrodite
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Amyloid self-assembly is linked to numerous devastating cell-degenerative diseases. However, designing inhibitors of this pathogenic process remains a major challenge. Cross-interactions between amyloid-β peptide (Aβ) and islet amyloid polypeptide (IAPP), key polypeptides of Alzheimer’s disease (AD) and type 2 diabetes (T2D), have been suggested to...
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Full title
Designed peptides as nanomolar cross-amyloid inhibitors acting via supramolecular nanofiber co-assembly
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TN_cdi_doaj_primary_oai_doaj_org_article_3b23585f88cb4b29866249912e9885cc
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_3b23585f88cb4b29866249912e9885cc
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-022-32688-0
