Modulation of brain cation-Cl− cotransport via the SPAK kinase inhibitor ZT-1a
Modulation of brain cation-Cl− cotransport via the SPAK kinase inhibitor ZT-1a
About this item
Full title
Author / Creator
Zhang, Jinwei , Bhuiyan, Mohammad Iqbal H. , Zhang, Ting , Karimy, Jason K. , Wu, Zhijuan , Fiesler, Victoria M. , Zhang, Jingfang , Huang, Huachen , Hasan, Md Nabiul , Skrzypiec, Anna E. , Mucha, Mariusz , Duran, Daniel , Huang, Wei , Pawlak, Robert , Foley, Lesley M. , Hitchens, T. Kevin , Minnigh, Margaret B. , Poloyac, Samuel M. , Alper, Seth L. , Molyneaux, Bradley J. , Trevelyan, Andrew J. , Kahle, Kristopher T. , Sun, Dandan and Deng, Xianming
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
The
SLC12A
cation-Cl
−
cotransporters (CCC), including NKCC1 and the KCCs, are important determinants of brain ionic homeostasis. SPAK kinase (
STK39
) is the CCC master regulator, which stimulates NKCC1 ionic influx and inhibits KCC-mediated efflux via phosphorylation at conserved, shared motifs. Upregulation of SPAK-dependent CC...
Alternative Titles
Full title
Modulation of brain cation-Cl− cotransport via the SPAK kinase inhibitor ZT-1a
Authors, Artists and Contributors
Author / Creator
Bhuiyan, Mohammad Iqbal H.
Zhang, Ting
Karimy, Jason K.
Wu, Zhijuan
Fiesler, Victoria M.
Zhang, Jingfang
Huang, Huachen
Hasan, Md Nabiul
Skrzypiec, Anna E.
Mucha, Mariusz
Duran, Daniel
Huang, Wei
Pawlak, Robert
Foley, Lesley M.
Hitchens, T. Kevin
Minnigh, Margaret B.
Poloyac, Samuel M.
Alper, Seth L.
Molyneaux, Bradley J.
Trevelyan, Andrew J.
Kahle, Kristopher T.
Sun, Dandan
Deng, Xianming
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_3b3910c818a141759af3688133b30605
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_3b3910c818a141759af3688133b30605
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-13851-6
