Dephosphorylation of the HIV-1 restriction factor SAMHD1 is mediated by PP2A-B55α holoenzymes during...
Dephosphorylation of the HIV-1 restriction factor SAMHD1 is mediated by PP2A-B55α holoenzymes during mitotic exit
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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SAMHD1 is a critical restriction factor for HIV-1 in non-cycling cells and its antiviral activity is regulated by T592 phosphorylation. Here, we show that SAMHD1 dephosphorylation at T592 is controlled during the cell cycle, occurring during M/G
1
transition in proliferating cells. Using several complementary proteomics and biochemical approa...
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Dephosphorylation of the HIV-1 restriction factor SAMHD1 is mediated by PP2A-B55α holoenzymes during mitotic exit
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TN_cdi_doaj_primary_oai_doaj_org_article_3b8f796c4d5d4e31b78e854d8aab59b2
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_3b8f796c4d5d4e31b78e854d8aab59b2
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-018-04671-1
