Large libraries of single-chain trimer peptide-MHCs enable antigen-specific CD8+ T cell discovery an...
Large libraries of single-chain trimer peptide-MHCs enable antigen-specific CD8+ T cell discovery and analysis
About this item
Full title
Author / Creator
Chour, William , Choi, Jongchan , Xie, Jingyi , Chaffee, Mary E. , Schmitt, Thomas M. , Finton, Kathryn , DeLucia, Diana C. , Xu, Alexander M. , Su, Yapeng , Chen, Daniel G. , Zhang, Rongyu , Yuan, Dan , Hong, Sunga , Ng, Alphonsus H. C. , Butler, Jonah Z. , Edmark, Rick A. , Jones, Lesley C. , Murray, Kim M. , Peng, Songming , Li, Guideng , Strong, Roland K. , Lee, John K. , Goldman, Jason D. , Greenberg, Philip D. and Heath, James R.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
The discovery and characterization of antigen-specific CD8
+
T cell clonotypes typically involves the labor-intensive synthesis and construction of peptide-MHC tetramers. We adapt single-chain trimer (SCT) technologies into a high throughput platform for pMHC library generation, showing that hundreds can be rapidly prepared across multiple Cl...
Alternative Titles
Full title
Large libraries of single-chain trimer peptide-MHCs enable antigen-specific CD8+ T cell discovery and analysis
Authors, Artists and Contributors
Author / Creator
Choi, Jongchan
Xie, Jingyi
Chaffee, Mary E.
Schmitt, Thomas M.
Finton, Kathryn
DeLucia, Diana C.
Xu, Alexander M.
Su, Yapeng
Chen, Daniel G.
Zhang, Rongyu
Yuan, Dan
Hong, Sunga
Ng, Alphonsus H. C.
Butler, Jonah Z.
Edmark, Rick A.
Jones, Lesley C.
Murray, Kim M.
Peng, Songming
Li, Guideng
Strong, Roland K.
Lee, John K.
Goldman, Jason D.
Greenberg, Philip D.
Heath, James R.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_3bdea162be0a4447904d5af92d6a6730
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_3bdea162be0a4447904d5af92d6a6730
Other Identifiers
ISSN
2399-3642
E-ISSN
2399-3642
DOI
10.1038/s42003-023-04899-8
